HCID 22458278, compound → HCID 59894961, compound

HRID 2185558Notes

Reaction equation

HRID 2185558 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][C:9]([NH:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)=[O:10].[CH:18]([C@@H:20]1[C@@H:24]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:23][N:22]([C@H:31]([CH:44]2[CH2:49][CH2:48][CH2:47][CH2:46][CH2:45]2)[C:32]([O:34]CC2C=CC(OC)=CC=2)=[O:33])[CH2:21]1)=O>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15]([CH2:18][C@@H:20]2[C@@H:24]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH2:23][N:22]([C@H:31]([CH:44]3[CH2:49][CH2:48][CH2:47][CH2:46][CH2:45]3)[C:32]([OH:34])=[O:33])[CH2:21]2)[CH2:14][CH2:13]1)=[O:10]

Participants

3

Reactant 2

HCID 22458278HCID 22458278, compoundHCID 53654320alpha-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-cyclohexaneacetic acid 4-methoxybenzyl ester

Product 1

HCID 59894961HCID 59894961, compound

Procedure

The title compound was prepared from 4-((2-methylphenyl)oxycarbonylamino)-piperidine and 2-(R)-(3-(R)-formyl-4-(S)phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, 4-methoxybenzyl ester (Aldehyde 5) according to the method described in Example 1, Step C. ESI-MS: 534 (M+H); HPLC A: 2.29 min.

Workup

  1. custom2.29 min.

Sources & evidence

ORD record
ord-c37796192b574554949e289e746ead66
Source dataset
uspto-grants-2002_06
Patent number
US06399619B1

Reaction notes

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