Trifluoroacetic acid methylene chloride → HCID 22458273, compound

HRID 2185569Notes

Reaction equation

HRID 2185569 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:25])[CH2:10][CH2:11][CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)=[CH:5][CH:4]=1)#[N:2].[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27].C(Cl)Cl>>[F:29][C:28]([F:31])([F:30])[C:26]([OH:32])=[O:27].[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9](=[O:25])[CH2:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[CH:7][CH:8]=1)#[N:2]

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 22458268HCID 22458268, compound

Product 1

HCID 22458273HCID 22458273, compound

Procedure

A solution of 4-(3-(4-cyanophenyl)-3-oxo-propyl)-1-tert-butoxycarbonyl-piperidine (75 mg) in 30% TFA/CH2Cl2 was stirred for 30 min then concentrated and dried under vacuum to provide the title compound.

Workup

  1. concentrationthen concentrated
  2. customdried under vacuum

Sources & evidence

ORD record
ord-021fdcf95c134d9799728850623293ec
Source dataset
uspto-grants-2002_06
Patent number
US06399619B1

Reaction notes

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