HCID 22458254, compound → HCID 21341083, compound

Participants

Reaction Steps

The title compound was prepared from 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, 4-(methoxy)benzyl ester (40 mg, 0.092 mmol, Aldehyde 5) and 4-(4-(4-fluorophenyl)-4-oxo-butyl)piperidine trifluoroacetate (43 mg, 0.119 mmol from Step D) using the procedure described in Example 26, Step F to provide 28 mg (56%) of the title compound. 1H NMR (500 MHz, CD3OD) δ1.15-1.5 (m, 9H), 1.58-2.05 (m, 10H), 2.33-2.35 (m, 1H), 2.49-2.52 (m, 1H), 2.7-2.8 (m, 2H), 2.92-2.94 (m, 1H), 2.95-2.98 (t, 2H, J=7), 3.1-3.13 (m, 1H), 3.3-4.8 (m, 6H), 7.18-7.21 (m, 2H) 7.26-7.29 (m, 1H), 7.31-7.34 (m, 4H), 8.01-8.5 (m, 2H). ESI-MS: 549 (M+H).

Provenance & Evidence