Sodium Carbonate → HCID 22858196, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of O-phenylmethyl-L-serine (50 g; 0.26 mol) in t-butyl acetate (1000 mL; 7.49 mol) 70% perchloric acid was added (50 mL; 0.58 mol). The solution was maintained under stirring for 72 h at 250° C. under inert atmosphere. The reaction mixture was diluted with Et2O (300 mL), then a 10% Na2CO3 aqueous solution was slowly added until pH 9 was reached. The organic layer was separated, dried over Na2SO4 and concentrated. The residual t-butyl acetate was distilled under reduced pressure (40° C.0.1 mm Hg). The desired product was obtained (54.2 g; 0.21 mol). Yield 83%.

Provenance & Evidence