HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hexylphenacyl bromide → Acetic Acid Mixture with Hydrobromic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hexylphenacyl bromide | HCID 12925264 | — |
| Reactant | 2,3-Difluoro-4-ethoxythiophenol | HCID 22450965 | — |
| Reactant | 4-Ethoxy-2,3-difluoroaniline | HCID 22450978 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| Product | 6,7-Difluoro-2-(4-hexylphenyl)-5-ethoxybenzo[b]thiophene | HCID 22450969 | — |
Reaction Steps
is obtained by reacting 2,3-difluoro-4-ethoxythiophenol (obtainable analogously to Reference 7 from 2,3-difluoro-4-ethoxyaniline [189751-13-1]) and 4-hexylphenacyl bromide analogously to Reference 5 to give 6,7-difluoro-2-(4-hexylphenyl)-5-ethoxybenzo[b]thiophene, ether cleavage by means of hydrobromic acid/acetic acid to give 6,7-difluoro-2-(4-hexylphenyl)-5-hydroxybenzo[b]thiophene and Williamson ether synthesis using heptyl bromide in 2-butanone in the presence of potassium carbonate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06403172B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-b6c8ec72c2fd4165b5f34a916f866cd8 |
| Source note | uspto-grants-2002_06 |