Morpholine, 4-(chloroacetyl)- → N-(4-isopropylphenyl)-N-(2-morpholino-2-oxoethyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide

HRID 218561Notes

Reaction equation

HRID 218561 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([CH:13]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16][CH2:15][CH2:14]2)=[O:12])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[O:23]1[CH2:28][CH2:27][N:26]([C:29](=[O:32])[CH2:30]Cl)[CH2:25][CH2:24]1>>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]([CH2:30][C:29]([N:26]2[CH2:27][CH2:28][O:23][CH2:24][CH2:25]2)=[O:32])[C:11]([CH:13]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16][CH2:15][CH2:14]2)=[O:12])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 74040Morpholine, 4-(chloroacetyl)-HCID 17854222HCID 17854222, compound

Product 1

HCID 10136939N-(4-isopropylphenyl)-N-(2-morpholino-2-oxoethyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamideYield 60%

Procedure

By the reaction and treatment in the same manner as in Example 6 using N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.5 g) and 2-morpholino-2-oxoethyl chloride (0.33 g) as starting materials, N-(4-isopropylphenyl)-N-(2-morpholino-2-oxoethyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.43g) was obtained. melting point: 180° C.

Sources & evidence

ORD record
ord-b551e8ae1c8742ad8ebe289af47e3b5b
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

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