Hydrochloric Acid → HCID 22451127, compound

Participants

Reaction Steps

To a solution containing the obtained ethyl 2-(2-chloro-4-fluoro-5-nitrophenoxy)-4-bromobutanoate (1 equivalent) in THF is added potassium t-butoxide (1 equivalent) at −15° C. and the mixture is stirred. After warming the reaction solution up to room temperature, to the solution is added aqueous diluted hydrochloric acid and extracted with ethyl acetate. After concentrating the organic layer, the residue is subjected to chromatography to give ethyl 1-(2-chloro-4-fluoro-5-nitrophenoxy)cyclopropanecarboxylate.

Provenance & Evidence