HCID 22451127, compound → HCID 22451125, compound

Participants

Reaction Steps

The obtained ethyl 1-(2-chloro-4-fluoro-5-nitro-phenoxy)cyclopropanecarboxylate (1 equivalent) is added dropwise to a mixture of acetic acid/ water (1/1) containing iron powders (3 equivalents) at 6° C. After completion of addition, the mixture is allowed to cool to room temperature and extracted with ethyl acetate. After concentrating the organic layer, the residue is subjected to chromatography to give ethyl 1-(2-chloro-4-fluoro-5-aminophenoxy)cyclopropanecarboxylate.

Provenance & Evidence