3,4-Dichlorobenzyl chloride → 3-(4-Chlorobenzyloxy)-1-(diphenylmethyl) azetidine

HRID 2185631Notes

Reaction equation

HRID 2185631 reaction equation
[C:1]1([CH:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:8]2[CH2:11][CH:10]([OH:12])[CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[C:23](Cl)[CH:22]=1>>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([CH2:20][O:12][CH:10]2[CH2:11][N:8]([CH:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:9]2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 76093,4-Dichlorobenzyl chlorideHCID 3304481-(Diphenylmethyl)azetidin-3-ol

Product 1

HCID 543278103-(4-Chlorobenzyloxy)-1-(diphenylmethyl) azetidineYield 92%

Procedure

This material was prepared from 1-diphenylmethyl-3-azetidinol (6.0 g) and alpha,3,4-trichlorotoluene using the procedure described for compound (1) (yield 92%).

Sources & evidence

ORD record
ord-31f51eb23ec34cc787f3306f2350bc6f
Source dataset
uspto-grants-2002_06
Patent number
US06403574B1

Reaction notes

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