7-Methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid → HCID 10157223, compound

HRID 218565Notes

Reaction equation

HRID 218565 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9][CH:10]2[C:13]([OH:15])=O)=[CH:5][CH:4]=1.[C:16]([CH2:18][CH2:19][CH2:20][NH:21][C:22]1[CH:27]=[CH:26][C:25]([CH:28]([CH3:30])[CH3:29])=[CH:24][CH:23]=1)#[N:17]>>[C:16]([CH2:18][CH2:19][CH2:20][N:21]([C:22]1[CH:23]=[CH:24][C:25]([CH:28]([CH3:30])[CH3:29])=[CH:26][CH:27]=1)[C:13]([CH:10]1[C:11]2[C:6](=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:12]=2)[CH2:7][CH2:8][CH2:9]1)=[O:15])#[N:17]

Participants

3

Reactant 2

HCID 132774847-Methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acidHCID 17854525HCID 17854525, compound

Product 1

HCID 10157223HCID 10157223, compoundYield 52.8%

Procedure

By the reaction and treatment in the same manner as in Example 1 using 7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (1.56 g) and (3-cyanopropyl) (4-isopropylphenyl)amine (1.79 g) as starting materials, N-(3-cyanopropyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.56 g) was obtained. melting point: 74-750° C.

Sources & evidence

ORD record
ord-4d6f56cef207402b94f76cbcdf553ae6
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

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