1,1-dioxo-3,4-dihydro-2H-1lambda6-benzothiopyran-4-carboxylic acid → N-[(4-dimethylaminophenyl) methyl]-N-(4-isopropylphenyl)-1,1-dioxothiochroman-4-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	1,1-dioxo-3,4-dihydro-2H-1lambda6-benzothiopyran-4-carboxylic acid	HCID 17854175	—
Reactant	N-(4-(Dimethylamino)benzyl)-4-isopropylbenzenamine	HCID 21957887	—
Product	N-[(4-dimethylaminophenyl) methyl]-N-(4-isopropylphenyl)-1,1-dioxothiochroman-4-carboxamide	HCID 10227465	12.8%

Reaction Steps

By the reaction and treatment in the same manner as in Example 1 using 1,1-dioxothiochroman-4-carboxylic acid (0.26 g) and [(4-dimethylaminophenyl)methyl](4-isopropylphenyl)amine (0.31 g) as starting materials, N-[(4-dimethylaminophenyl) methyl]-N-(4-isopropylphenyl)-1,1-dioxothiochroman-4-carboxamide (0.07 g) was obtained. melting point: 185-187° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08198454B2
Source dataset	uspto-grants-2012_06
ORD ID	ord-38d1a942ac264d6c8504fabc71a9e0d0
Source note	uspto-grants-2012_06