Methyl 4-ethoxy-2,3-dihydro-1H-indole-2-carboxylate → HCID 77752378, compound

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Reaction Steps

Methyl 4-ethoxyindoline-2(R/S)-carboxylate (0.84 g, 3.8 mmol) was dissolved in butylamine (40 ml), under nitrogen, and the solution was then stirred at reflux for three hours. After cooling the mixture, the remaining butylamine was removed under vacuum. The crude product was purified by chromatography on a column of silica gel, using a 5/5 petroleum ether/ethyl acetate mixture as eluent. A yellow solid was obtained.

Provenance & Evidence