HCID 22451239, compound → HCID 77751992, compound

HRID 2185694Notes

Reaction equation

HRID 2185694 reaction equation
[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][CH:6]([C:14]([O:16]C)=O)[NH:7]2>C(N)CCC>[CH2:6]([NH:7][C:14]([CH:6]1[CH2:5][C:4]2[C:8](=[CH:9][CH:10]=[C:11]([O:12][CH3:13])[C:3]=2[O:2][CH3:1])[NH:7]1)=[O:16])[CH2:5][CH2:4][CH3:3]

Participants

3

Reactant 1

HCID 22451239HCID 22451239, compound

Product 1

HCID 77751992HCID 77751992, compound

Reagents, catalysts & solvents 1

HCID 8007ButylamineSolvent

Procedure

Methyl 4,5-dimethoxyindoline-2(R/S)-carboxylate (0.447 g, 1.89 mmol) was dissolved in butylamine (35 ml), under nitrogen, and the solution was then stirred at reflux for three hours. After cooling the mixture, the remaining butylamine was removed under vacuum. The crude product was recrystallized from diethyl ether to give an off-white solid.

Workup

  1. temperatureat reflux for three hours
  2. temperatureAfter cooling the mixture
  3. customthe remaining butylamine was removed under vacuum
  4. customThe crude product was recrystallized from diethyl ether
  5. customto give an off-white solid

Sources & evidence

ORD record
ord-666a3ca7a11a4181b9854320698180f8
Source dataset
uspto-grants-2002_06
Patent number
US06403561B1

Reaction notes

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