185212-39-9 → HCID 85707549, compound

HRID 2185697Notes

Reaction equation

HRID 2185697 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]([C:11]([O:13]C)=O)[CH2:5]2>C(N)CCC>[CH2:6]([NH:7][C:11]([CH:6]1[CH2:5][C:4]2[C:8](=[CH:9][CH:10]=[C:2]([CH3:1])[CH:3]=2)[NH:7]1)=[O:13])[CH2:5][CH2:4][CH3:3]

Participants

3

Reactant 1

HCID 22451281185212-39-9

Product 1

HCID 85707549HCID 85707549, compound

Reagents, catalysts & solvents 1

HCID 8007ButylamineSolvent

Procedure

Methyl 5-methylindoline-2(R/S)-carboxylate (0.3 g, 4.18 mmol) was dissolved in butylamine (20 ml) and the mixture was refluxed for 4 h under nitrogen. The excess amine was removed under vacuum to give a solid, which was recrystallized from ether in order to allow the product to be collected.

Workup

  1. temperaturethe mixture was refluxed for 4 h under nitrogen
  2. customThe excess amine was removed under vacuum
  3. customto give a solid, which
  4. customwas recrystallized from ether in order
  5. customto be collected

Sources & evidence

ORD record
ord-239c0ba8916541089e8bd93385a52246
Source dataset
uspto-grants-2002_06
Patent number
US06403561B1

Reaction notes

Loading…