HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 5-chloro-1H-indole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 5-Chloro-1H-indole-2-carboxylic acid | HCID 82693 | — |
| Product | Methyl 5-chloro-1H-indole-2-carboxylate | HCID 4777711 | — |
Reaction Steps
5-Chloroindole-2-carboxylic acid (0.95 g, 4.65 mmol) was dissolved in methanol (35 ml) and treated with sulphuric acid (0.5 ml). The mixture was refluxed for 5 h and cooled and the solvent was removed. The residue was recrystallized twice from methanol to give the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06403561B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-1843d09476d94f2d81b51943c44e87d1 |
| Source note | uspto-grants-2002_06 |