1-Bromo-2-Chloroethane → 2-(2-Chloroethyl)-4-ethyoxycarbonyl-6-(4-methoxyphenyl)-2H-pyridazin-3-one

HRID 2185783Notes

Reaction equation

HRID 2185783 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7](=[O:20])[NH:8][N:9]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)[CH:11]=1)=[O:5])[CH3:2].Br[CH2:22][CH2:23][Cl:24]>>[Cl:24][CH2:23][CH2:22][N:8]1[C:7](=[O:20])[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])=[CH:11][C:10]([C:12]2[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=2)=[N:9]1

Participants

3

Reactant 2

HCID 78491-Bromo-2-ChloroethaneHCID 22452278HCID 22452278, compound

Product 1

HCID 154535422-(2-Chloroethyl)-4-ethyoxycarbonyl-6-(4-methoxyphenyl)-2H-pyridazin-3-oneYield 88.8%

Procedure

Using 4-ethoxycarbonyl-6-(4-methoxyphenyl)-2H-pyridazin-3-one and 1-bromo-2-chloroethane as starting materials, the procedures of Example 1 were repeated likewise, whereby the title compound was obtained in a yield of 88.8%.

Sources & evidence

ORD record
ord-49ceb1f7b58e44dc8bd80cf4be74c8ac
Source dataset
uspto-grants-2002_06
Patent number
US06403586B1

Reaction notes

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