Ethylamine → 2-Cyclopentylmethyl-4-ethylcarbamoyl-6-(4-methoxyphenyl)-2H-pyridazin-3-one

HRID 2185814Notes

Reaction equation

HRID 2185814 reaction equation
[CH:1]1([CH2:6][N:7]2[C:12](=[O:13])[C:11]([C:14](OCC)=[O:15])=[CH:10][C:9]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)=[N:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:27]([NH2:29])[CH3:28]>CO>[CH:1]1([CH2:6][N:7]2[C:12](=[O:13])[C:11]([C:14](=[O:15])[NH:29][CH2:27][CH3:28])=[CH:10][C:9]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)=[N:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6341EthylamineHCID 22452171HCID 22452171, compound

Product 1

HCID 224522662-Cyclopentylmethyl-4-ethylcarbamoyl-6-(4-methoxyphenyl)-2H-pyridazin-3-oneYield 82.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In methanol, 2-cyclopentylmethyl-4-ethoxycarbonyl-6-(4-methoxyphenyl)-2H-pyridazin-3-one and a 70% aqueous solution of ethylamine were processed as in Example 43, whereby the title compound was obtained in a yield of 82.2%.

Sources & evidence

ORD record
ord-3ffc2519b4d74770ac47350c63538822
Source dataset
uspto-grants-2002_06
Patent number
US06403586B1

Reaction notes

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