2-(Bromomethyl)pyridine → HCID 70174888, compound

HRID 2185820Notes

Reaction equation

HRID 2185820 reaction equation
[Cl:1][C:2]1[CH:31]=[CH:30][C:5]([CH:6]=[CH:7][CH2:8][N:9]2[C:14](=[O:15])[C:13]([NH:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:12][C:11]([C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=3)=[N:10]2)=[CH:4][CH:3]=1.[N:32]1[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=1[CH2:38]Br>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:6]=[CH:7][CH2:8][N:9]2[C:14](=[O:15])[C:13]([N:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:38][C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][N:32]=3)=[CH:12][C:11]([C:22]3[CH:23]=[CH:24][C:25]([O:28][CH3:29])=[CH:26][CH:27]=3)=[N:10]2)=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 5642092-(Bromomethyl)pyridineHCID 54496364HCID 54496364, compound

Product 1

HCID 70174888HCID 70174888, compoundYield 97%

Procedure

2-(4-Chlorocinnamyl)-4-ethoxycarbonylamino-6-(4-methoxyphenyl)-2H-pyridazin-3-one (70 mg) and 2-pyridylmethyl bromide were processed as in Example 116 (stirred at 70° C. for 4 hours), whereby the title compound (82 mg, 97.0%) was obtained.

Sources & evidence

ORD record
ord-934433d50124461fb5deaa1aa5fc02b6
Source dataset
uspto-grants-2002_06
Patent number
US06403586B1

Reaction notes

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