N-Methylbenzylamine → HCID 22452596, compound

Participants

Reaction Conditions

Reaction Steps

To 5-(2-methylsulfonylpyrimidin-4-yl)-2-oxo-6-(3-trifluoromethylphenyl)-1,2-dihydropyridine-3-carbonitrile (150 mg, 0.357 mmol) in a sealed tube was added (S)-∝-methylbenzylamine (150 mg) and the mixture heated under argon at 100° C. for 1 hour. The reaction was cooled and the oil dissolved in ethyl acetate (25 mL). The solution was washed 3 times with a pH 5.3 buffer solution of 10% citric acid/NaOH (15 mL). The ethyl acetate layer was dried over sodium sulfate concentrated and chromatographed on silica using 80% ethyl acetate/hexane to give 120 mg (73%) of the title compound as a solid. The solid was stirred in methanol/hexane (2 mL) for 1 hour, filtered, and dried 40° C. to give 105 mg of a solid.

Provenance & Evidence