7-Methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid → HCID 10203524, compound

HRID 218584Notes

Reaction equation

HRID 218584 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9][CH:10]2[C:13]([OH:15])=O)=[CH:5][CH:4]=1.[C:16]([C:18]1[CH:23]=[CH:22][C:21]([CH2:24][NH:25][C:26]2[CH:31]=[CH:30][C:29]([CH:32]([CH3:34])[CH3:33])=[CH:28][CH:27]=2)=[CH:20][CH:19]=1)#[N:17]>>[C:16]([C:18]1[CH:19]=[CH:20][C:21]([CH2:24][N:25]([C:26]2[CH:31]=[CH:30][C:29]([CH:32]([CH3:34])[CH3:33])=[CH:28][CH:27]=2)[C:13]([CH:10]2[C:11]3[C:6](=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:12]=3)[CH2:7][CH2:8][CH2:9]2)=[O:15])=[CH:22][CH:23]=1)#[N:17]

Participants

3

Reactant 2

HCID 132774847-Methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acidHCID 28449596[(4-Cyanophenyl)methyl](4-isopropylphenyl)amine

Product 1

HCID 10203524HCID 10203524, compoundYield 47%

Procedure

By the reaction and treatment in the same manner as in Example 1 using 7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (0.63 g) and [(4-cyanophenyl)methyl](4-isopropylphenyl)amine (0.83 g) as starting materials, N-[(4-cyanophenyl)methyl]-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.63 g) was obtained. melting point: 137-138° C.

Sources & evidence

ORD record
ord-7d20187f2008498fa1a966bcebad165e
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

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