6-Fluoro-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid → N-[(4-dimethylaminophenyl)methyl]-6-fluoro-N-(4-isopropylphenyl)chroman-4-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	6-Fluoro-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid	HCID 13953799	—
Reactant	N-(4-(Dimethylamino)benzyl)-4-isopropylbenzenamine	HCID 21957887	—
Product	N-[(4-dimethylaminophenyl)methyl]-6-fluoro-N-(4-isopropylphenyl)chroman-4-carboxamide	HCID 10182151	64.8%

Reaction Steps

By the reaction and treatment in the same manner as in Example 1 using 6-fluorochroman-4-carboxylic acid (1.96 g) and [(4-dimethylaminophenyl)methyl] (4-isopropylphenyl) amine (2.68 g) as starting materials, N-[(4-dimethylaminophenyl)methyl]-6-fluoro-N-(4-isopropylphenyl)chroman-4-carboxamide (2.89 g) was obtained. melting point: 95-98° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08198454B2
Source dataset	uspto-grants-2012_06
ORD ID	ord-2404d6b41e504e96b0614c6a4865d78f
Source note	uspto-grants-2012_06