5,6,7,8-Tetrahydronaphthalene-1-carbonyl chloride → N-[(S)-2-(3,4-Dichlorophenyl)-4-[4-[tetrahydro-2-oxo-1(2H)-pyrimidinyl]-1-piperidinyl]butyl]-N-methyl-5,6,7,8-tetrahydro-1-naphthamide

Participants

Reaction Steps

Using standard acylation conditions N-[(S)-2-(3,4-dichlorophenyl)4-[4-[tetrahydro-2-oxo-1(2H)-pyrimidinyl]-1-piperidinyl]butyl]-N-methylamine (S. C. Miller,. WO 9505377) was reacted with 5,6,7,8-tetrahydro-1-naphthalenecarbonyl chloride (Example 1) and the product was converted to the citrate salt MS: m/z 571 (M+H). Analysis for C31H40O2Cl2N4.C6H8O7.3.0H2O: calculated: C,54.34; H, 6.66; N, 6.85; found: C, 54.26; H, 5.97; N, 6.47.

Provenance & Evidence