3-Hydroxy-2-naphthoic acid → 25435-10-3

Participants

Reaction Steps

A mixture of 3-hydroxy-2-naphthalenecarboxylic acid (15.0 g, 0.08 moles), 10% Pd/C (4.46 g) and acetic acid (190 mL) was hydrogenated at 60° C. and 50 psi for 7 h. The cooled reaction mixture was filtered through diatomaceous earth and washed with ethanol (4×25 mL). The yellow filtrate was concentrated in vacuo to afford 13.82 g (91%) of a purple solid. 1H NMR (CDCl3) δ 7.61 (s, 1H), 6.71 (s, 1H), 2.74 (d, 4H), 1,78 (s, 4H). MS m/z 191 (M−H).

Provenance & Evidence