反应详情

A mixture of 2-methoxy-1-naphthalenecarboxylic acid (1.0 g, 4.95 mmol) and 10% Pd/C (0.3 g) in HOAc (25 mL) was hydrogenated on Parr apparatus at 60° C. and 50 psi for 23 h. After filtration through diatomaceous earth, the solvent was removed under reduced pressure, and water was added. The solid was filtered and washed with water to give product as a yellow solid (0.377 g, 37%). 1H NMR (DMSO-d6) δ 12.81 (s, 1H), 7.05 (d, 1H), 6.83 (d, 1H), 3.68 (s, 3H), 2.66 (s, 2H), 2.59 (s, 2H), 1.69 (m, 4H); MS m/z 205 (M−H).

1. customwas hydrogenated on Parr apparatus at 60° C.
2. filtrationAfter filtration through diatomaceous earth
3. customthe solvent was removed under reduced pressure, and water
4. additionwas added
5. filtrationThe solid was filtered
6. washwashed with water