HCID 22452679, compound → HCID 22452660, compound

Participants

Reaction Steps

A mixture of 3,4-dimethoxy-1-naphthalenecarboxylic acid (2.34 g, 10.1 mmol) and 10% Pd/C (0.56 g) in HOAc (50 mL) was hydrogenated on Parr apparatus at 60° C. and 50 psi for 14 h. After filtration through diatomaceous earth, the solvent was removed in vacuo and water was added. The solid was collected by filtration and washed with water to yield the title compound as a yellow solid (2.21 g, 93%). 1H NMR (DMSO-d6) δ 12.69 (s, 1H), 7.30 (s, 1H), 3.79 (s, 3H), 3.73 (s, 3H), 2.91 (s, 2H), 2.65 (s, 2H), 1.64 (m, 4H); MS m/z 235 (M−H).

Provenance & Evidence