HCID 22452635, compound → HCID 22452630, compound

Participants

Reaction Steps

A mixture of 2,3-dimethoxy-1-naphthalenecarboxylic acid (2.21 g, 9.52 mmol) and 10% Pd/C (0.53 g) in HOAc (50 mL) was hydrogenated on a Parr apparatus at 60° C. and 50 psi for 11 h. After filtration through diatomaceous earth, the solvent was removed under reduced pressure, and water was added. The precipitate was filtered and washed with water to give the product as a white solid (1.62 g, 72%). 1H NMR (DMSO-d6) δ 12.99 (s, 1H), 6.77 (s,1H), 3.77 (s, 3H), 3.68 (s, 3H), 2.67 (s, 2H), 2.50 (s, 2H), 1.68 (m, 4H); MS m/z 235 (m−H).

Provenance & Evidence