HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-(Methylsulfonyl)phenyl)piperidine → N-[2-(3,4-Difluorophenyl)-4-[4-[2-methylsulfonylphenyl]-1-piperidinyl]butyl]-N-methyl-5,6,7,8-tetrahydro-1-naphthamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-(Methylsulfonyl)phenyl)piperidine | HCID 22452668 | — |
| Reactant | N-[2-(3,4-difluorophenyl)-4-oxobutyl]-N-methyl-5,6,7,8-tetrahydro-1-naphthamide | HCID 22452683 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-[2-(3,4-Difluorophenyl)-4-[4-[2-methylsulfonylphenyl]-1-piperidinyl]butyl]-N-methyl-5,6,7,8-tetrahydro-1-naphthamide | HCID 22452689 | — |
Reaction Steps
Using standard reductive amination conditions N-[2-(3,4-difluorophenyl)-4-oxobutyl]-N-methyl-5,6,7,8-tetrahydro-1-naphthamide was reacted with 4-[2-methylsulfonylphenyl]piperidine and converted to the citrate salt. MS: m/z 595 (M+H). Analysis for C34H40F2N2O3S.C6H8O7.1.4 H2O: calculated: C, 59.16; H, 6.31; N, 3.45; found: C, 59.04; H, 6.10; N, 4.08.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06403601B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-b198e5e829f046c9a936ee585b7a32f2 |
| Source note | uspto-grants-2002_06 |