1-(Piperidin-4-yl)-1,3-diazinan-2-one → N-(4-[4-(Tetrahydro-2-oxo-1(2H)-pyrimidinyl)-1-piperidinyl]-2-(4-chlorophenyl)-butyl)-N-methyl-5,6,7,8-tetrahydro-1-naphthamide

Participants

Reaction Steps

Using standard reductive amination conditions N-[2-(4-chlorophenyl)-4-oxobutyl]-N-methyl-5,6,7,8-tetrahydro-1-naphthamide was reacted with with 4-(tetrahydro-2-oxo-1(2H)-pyrimidinyl)piperidine and converted to the citrate salt. MS: m/z 537 (M+H). Analysis for C3H41CIN4O2.C6H8O7. H2O: calculated: C, 59.36; H, 6.87; N, 7.46; found: C, 59.42; H, 6.71; N, 7.12.

Provenance & Evidence