HCID 22452562, compound → HCID 22452564, compound

Participants

Reaction Steps

The title compound was synthesised following the procedure described for Compound 2C, except that Compound 3A was used instead of Compound 2B. The reaction was carried out at 40° C. Treatment of the reaction mixture with sodium dithionite and extraction with chloroform afforded a crude which was rinsed with 50 mL of ethyl acetate, boiled for 2 hours and filtered to give a first crop of Compound 3B. The mother liquor was evaporated and the residue was purified by flash chromatography (ethyl acetate/petroleum ether/glacial acetic acid 50:50:1) to give a second crop of Compound 3B. Total yield: 34%.

Provenance & Evidence