6-Chloro-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid → HCID 10139630, compound

HRID 218593Notes

Reaction equation

HRID 218593 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][CH2:7][CH2:6][CH:5]2[C:12]([OH:14])=O.[CH3:15][N:16]([CH3:34])[C:17]1[CH:22]=[CH:21][C:20]([CH2:23][NH:24][C:25]2[CH:30]=[CH:29][C:28]([CH:31]([CH3:33])[CH3:32])=[CH:27][CH:26]=2)=[CH:19][CH:18]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][CH2:7][CH2:6][CH:5]2[C:12]([N:24]([CH2:23][C:20]1[CH:19]=[CH:18][C:17]([N:16]([CH3:34])[CH3:15])=[CH:22][CH:21]=1)[C:25]1[CH:26]=[CH:27][C:28]([CH:31]([CH3:33])[CH3:32])=[CH:29][CH:30]=1)=[O:14]

Participants

3

Reactant 2

HCID 139537956-Chloro-3,4-dihydro-2H-1-benzopyran-4-carboxylic acidHCID 21957887N-(4-(Dimethylamino)benzyl)-4-isopropylbenzenamine

Product 1

HCID 10139630HCID 10139630, compoundYield 25.1%

Procedure

By the reaction and treatment in the same manner as in Example 12 using 6-chlorochroman-4-carboxylic acid (0.66 g) and [(4-dimethylaminophenyl)methyl](4-isopropylphenyl)amine (0.83 g) as starting materials, 6-chloro-N-[(4-dimethylaminophenyl)methyl]-N-(4-isopropylphenyl)chroman-4-carboxamide (0.36 g) was obtained.

Sources & evidence

ORD record
ord-6e01be570caa469fbda344efcc295837
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

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