Hydrochloric Acid → HCID 131723265, compound

Participants

Reaction Steps

N-(N-(BOC)-3-phenylsulfonyl)-nipecotyl)-(L)-4-(2-ethyl-4-thiazolyl)-phenylalanine, methyl ester (60 mg, 0.0925 mmol) was dissolved in 2.5 mL of MeOH and treated with 280 μL of 0.5 N NaOH. The reaction mixture was stirred overnight, acidified to pH=2-3 with 1.2 N HCl, and concentrated under vacuo to give a white solid. This solid was purified by preparative TLC on silica gel eluted with CH2Cl2:MeOH:AcOH (v/v/v 95:5:0.5) to afford N-(N-(BOC)-3-phenylsulfonyl)-nipecotyl)-(L)-4-(2-ethyl-4-thiazolyl)phenylalanine (34.9 mg).

Provenance & Evidence