HCID 17854493, compound → HCID 10115382, compound

HRID 218596Notes

Reaction equation

HRID 218596 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[O:11][CH2:10][CH2:9][CH:8]2[C:13]([OH:15])=O.[CH3:16][N:17]([CH3:35])[C:18]1[CH:23]=[CH:22][C:21]([CH2:24][NH:25][C:26]2[CH:31]=[CH:30][C:29]([CH:32]([CH3:34])[CH3:33])=[CH:28][CH:27]=2)=[CH:20][CH:19]=1>>[CH3:16][N:17]([CH3:35])[C:18]1[CH:19]=[CH:20][C:21]([CH2:24][N:25]([C:26]2[CH:31]=[CH:30][C:29]([CH:32]([CH3:33])[CH3:34])=[CH:28][CH:27]=2)[C:13]([CH:8]2[C:7]3[C:12](=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][CH:6]=3)[O:11][CH2:10][CH2:9]2)=[O:15])=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 17854493HCID 17854493, compoundHCID 21957887N-(4-(Dimethylamino)benzyl)-4-isopropylbenzenamine

Product 1

HCID 10115382HCID 10115382, compoundYield 48.9%

Procedure

By the reaction and treatment in the same manner as in Example 12 using 8-methoxychroman-4-carboxylic acid, (0.64 g) and [(4-dimethylaminophenyl)methyl](4-isopropylphenyl)amine (0.83 g) as starting materials, N-[(4-dimethylaminophenyl)methyl]-N-(4-isopropylphenyl)-8-methoxychroman-4-carboxamide (0.69 g) was obtained.

Sources & evidence

ORD record
ord-010889f29ce0461ba75a29ebcc5ec259
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

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