HCID 22455949, compound → HCID 22455946, compound

Participants

Reaction Conditions

Reaction Steps

Through a solution of N-t-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-hydroxy piperidine (150 mg, 0.44 mmol) in ethyl acetate (5 ml) cooled to 0° C. is bubbled HCl (g) for 5 min. The reaction mixture is stirred at 25° C. until reaction completion. The reaction mixture is concentrated in vacuo and flushed with ethyl acetate/concentrated 3 times to provide 3-(3,4-dichlorophenyl)-3-hydroxy piperidine hydrochloride which is converted without further purification to 3-(3,4-dichlorophenyl)-3-hydroxy piperidine-1-carboxylic acid {4-[(2,2-dimethyl-propionylamino)-methyl]-phenyl}-amide using N-(4-isocyanato-benzyl)-2,2-dimethyl-propionamide as described in example 1a.

Provenance & Evidence