関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 1-methyl-1H-1,3-benzodiazol-5-amine | HCID 315499 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 1-Methyl-4-bromo-5-aminobenzimidazole | HCID 12968451 | 50% |
反応手順
To a solution of 1-methyl-5-aminobenzimidazole (0.36 g, 2.4 mmol) in 10 ml of AcOH was added Br2 (0.12 ml). The reaction mixture was stirred for 1 h at 25° C. and concentrated in vacuo, yielding an oil which was subjected to column chromatography (NH3 sat'd 3% MeOH/CHCl3) to yield 0.27 g (1.2 mmol, 50%) of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06403626B1 |
|---|
| 出典データセット | uspto-grants-2002_06 |
|---|
| ORD ID | ord-d755f3afb18a41dea677b593155dc565 |
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| 出典メモ | uspto-grants-2002_06 |
|---|
