HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-Benzyl-4-bromo-5-aminobenzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 1-Benzyl-1H-benzimidazol-5-amine | HCID 1089058 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-Benzyl-4-bromo-5-aminobenzimidazole | HCID 18379821 | 60% |
Reaction Steps
To a solution of 1-benzyl-5-aminobenzimidazole (1.0 g, 5.0 mmol) in 40 ml of AcOH was added solution of Br2 in AcOH until it produces a precipitate. The reaction mixture was concentrated in vacuo to provide a brown solid which was subjected to column chromatography (5% NH3 sat'd MeOH/CHC13) to provide 0.90g (2.5 mmol, 60%) of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06403626B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-b348c9b5c7bf48378f0db12df33a228f |
| Source note | uspto-grants-2002_06 |