HCID 69929472, compound → HCID 69930827, compound

HRID 2186178Notes

Reaction equation

HRID 2186178 reaction equation
[CH2:1]([O:8][CH2:9][C@@H:10]1[N:15]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:14]=[CH:13][N:12]([CH2:23][C:24]2[CH:29]=[CH:28][C:27]([N:30]3[CH:34]=[CH:33][N:32]=[CH:31]3)=[CH:26][CH:25]=2)[C:11]1=[O:35])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C.[Pd]>[CH2:1]([O:8][CH2:9][C@@H:10]1[N:15]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:14][CH2:13][N:12]([CH2:23][C:24]2[CH:29]=[CH:28][C:27]([N:30]3[CH:34]=[CH:33][N:32]=[CH:31]3)=[CH:26][CH:25]=2)[C:11]1=[O:35])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 69929472HCID 69929472, compound

Product 1

HCID 69930827HCID 69930827, compoundYield 89.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

In ethanol (80 ml) was dissolved (S)-3-benzyloxymethyl-4-(tert-butoxycarbonyl)-1-[4-(1H-imidazol-1-yl)benzyl]-2-oxo-1,2,3,4-tetrahydropyrazine (1.13 g), and to the solution was added 10% palladium on carbon (1 g). The mixture was subjected to catalytic reduction for 9 hours with medium pressure reduction apparatus, and the catalyst was removed. The solvent was evaporated under reduced pressure to give colorless amorphous of the title compound (1.02 g).

Workup

  1. customthe catalyst was removed
  2. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-747cf4ff7c224f7ca4f936ed8f28a2c3
Source dataset
uspto-grants-2002_06
Patent number
US06403595B1

Reaction notes

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