反应详情

To a solution of 1-(4-cyanobenzyl)-4-vinylsulfonyl-2-piperazinone (1.53 g) and 4-chlorosalicylaldehyde (0.94 g) in tert-butanol (20 ml) was added potassium tert-butoxide (187 mg), and the mixture was refluxed for 4 days. The reaction solution was concentrated under reduced pressure, and precipitated crystals were washed with acetone-ethanol to give pale brown crystals of the title compound (0.88 g).

1. temperaturethe mixture was refluxed for 4 days
2. concentrationThe reaction solution was concentrated under reduced pressure
3. customprecipitated crystals
4. washwere washed with acetone-ethanol