HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Fluoro-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid → N-[(1-ethylpyrazol-4-yl)methyl]-6-fluoro-N-(4-isopropylphenyl)chroman-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Fluoro-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid | HCID 13953799 | — |
| Reactant | N-((1-Ethyl-1H-pyrazol-4-yl)methyl)-4-isopropylaniline | HCID 21957909 | — |
| Product | N-[(1-ethylpyrazol-4-yl)methyl]-6-fluoro-N-(4-isopropylphenyl)chroman-4-carboxamide | HCID 59597401 | 67.4% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 12 using 6-fluorochroman-4-carboxylic acid (0.29 g) and [(1-ethylpyrazol-4-yl)methyl](4-isopropylphenyl)amine (0.37 g) as starting materials, N-[(1-ethylpyrazol-4-yl)methyl]-6-fluoro-N-(4-isopropylphenyl)chroman-4-carboxamide (0.42 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08198454B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-03a8dcc5370c44c0830417a68bebc7f4 |
| Source note | uspto-grants-2012_06 |