6,7,8,9-tetrahydro-5H-benzo(7)annulene-5-carboxylic acid → N-[(1-ethylpyrazol-4-yl)methyl]-N-(4-isopropylphenyl)-6,7,8,9-tetrahydro-5H-benzocycloheptene-5-carboxamide
Reaction equation
[CH:1]1[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][CH:11]([C:12]([OH:14])=O)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH2:15]([N:17]1[CH:21]=[C:20]([CH2:22][NH:23][C:24]2[CH:29]=[CH:28][C:27]([CH:30]([CH3:32])[CH3:31])=[CH:26][CH:25]=2)[CH:19]=[N:18]1)[CH3:16]>>[CH2:15]([N:17]1[CH:21]=[C:20]([CH2:22][N:23]([C:24]2[CH:25]=[CH:26][C:27]([CH:30]([CH3:31])[CH3:32])=[CH:28][CH:29]=2)[C:12]([CH:11]2[C:5]3[CH:4]=[CH:3][CH:2]=[CH:1][C:6]=3[CH2:7][CH2:8][CH2:9][CH2:10]2)=[O:14])[CH:19]=[N:18]1)[CH3:16]Participants
3
Procedure
By the reaction and treatment in the same manner as in Example 12 using 6,7,8,9-tetrahydro-5H-benzocycloheptene-5-carboxylic acid (0.29 g) and [(1-ethylpyrazol-4-yl)methyl](4-isopropylphenyl)amine (0.37 g) as starting materials, N-[(1-ethylpyrazol-4-yl)methyl]-N-(4-isopropylphenyl)-6,7,8,9-tetrahydro-5H-benzocycloheptene-5-carboxamide (0.36 g) was obtained.
Sources & evidence
- ORD record
- ord-40128212572a4fbe8a6381a6bddd6a03
- Source dataset
- uspto-grants-2012_06
- Patent number
- US08198454B2
Reaction notes
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