5-Methoxy-2,3-dihydro-1H-indene-1-carboxylic acid → HCID 59597192, compound

HRID 218626Notes

Reaction equation

HRID 218626 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH:8]([C:12]([OH:14])=O)[CH2:7][CH2:6]2.[CH2:15]([N:17]1[CH:21]=[C:20]([CH2:22][NH:23][C:24]2[CH:29]=[CH:28][C:27]([CH:30]([CH3:32])[CH3:31])=[CH:26][CH:25]=2)[CH:19]=[N:18]1)[CH3:16]>>[CH2:15]([N:17]1[CH:21]=[C:20]([CH2:22][N:23]([C:24]2[CH:25]=[CH:26][C:27]([CH:30]([CH3:31])[CH3:32])=[CH:28][CH:29]=2)[C:12]([CH:8]2[C:9]3[C:5](=[CH:4][C:3]([O:2][CH3:1])=[CH:11][CH:10]=3)[CH2:6][CH2:7]2)=[O:14])[CH:19]=[N:18]1)[CH3:16]

Participants

3

Reactant 2

HCID 138400075-Methoxy-2,3-dihydro-1H-indene-1-carboxylic acidHCID 21957909N-((1-Ethyl-1H-pyrazol-4-yl)methyl)-4-isopropylaniline

Product 1

HCID 59597192HCID 59597192, compoundYield 74.6%

Procedure

By the reaction and treatment in the same manner as in Example 4 using 5-methoxyindan-1-carboxylic acid (0.29 g) and [(1-ethylpyrazol-4-yl)methyl](4-isopropylphenyl)amine (0.37 g) as starting materials, N-[(1-ethylpyrazol-4-yl)methyl]-N-(4-isopropylphenyl)-5-methoxyindan-1-carboxamide (0.47 g) was obtained. melting point: 115-116° C.

Sources & evidence

ORD record
ord-ea8feb371c134833b46eed1f361e4b59
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

Loading…