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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2186262Generated: October 30, 2026

5-Benzyloxy-4-t-butyl-2-(1-octenyl)benzofuran → 4-Tert-butyl-5-hydroxy-2-octylbenzofuran

https://huagongshe.com/reaction/2186262

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Benzyloxy-4-t-butyl-2-(1-octenyl)benzofuranHCID 54308722—
CatalystPalladiumHCID 23938—
SolventAcetic AcidHCID 176—
Product4-Tert-butyl-5-hydroxy-2-octylbenzofuranHCID 2344286470.4%

Reaction Steps

Under hydrogen atmosphere, a solution of 1.1 g of 5-benzyloxy-4-t-butyl-2-(1-octenyl)benzofuran in 50 ml of acetic acid was stirred with 1.1 g of 10% palladium on carbon for 36 hours. After the palladium on carbon was filtered out, the filtrate was concentrated and the concentrate was purified by silica gel column chromatography (in chloroform) to give 0.6 g of 4-t-butyl-5-hydroxy-2-n-octylbenzofuran as a pale yellow oil (yield 69%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06403639B1
Source datasetuspto-grants-2002_06
ORD IDord-ed523744bd7b41779a4d68e23dcc2d61
Source noteuspto-grants-2002_06