Hydrochloric Acid → HCID 70174515, compound

Participants

Reaction Steps

8.8 g of (3R,4R)-1-benzoyl-4-[3-(6-methoxyquinolin-4-yl)propyl]piperidine-3-carboxylic acid were heated, with stirring, in 200 cm3 of 5N aqueous hydrochloric acid at a temperature in the region of 100° C. for 48 hours. The reaction mixture was concentrated under reduced pressure (5 kPa) at a temperature in the region of 50° C. The residue was taken up in 100 cm3 of acetone. The mixture was concentrated under reduced pressure (5 kPa) at a temperature in the region of 60° C. This operation was repeated an additional two times. The residue was finally triturated in 100 cm3 of acetone until it crystallized. After filtering off the crystals and drying in a desiccator under reduced pressure (10 kPa), 7.2 g of (3R,4R)-4-[3-(6-methoxyquinolin4-yl)propyl]piperidine-3-carboxylic acid hydrochloride were obtained in the form of a beige solid melting at approximately 270° C. (melting with softening).

Provenance & Evidence