Water → HCID 69354268, compound

Participants

Reaction Steps

18.4 cm3 of triethylamine were added to a stirred solution of 20.8 g of (3R,4R)-4-[3-(6-methoxyquinolin-4-yl)propyl]-3-vinylpiperidine in 270 cm3 of chloroform, followed, over 1 hour, by a solution of 7.2 cm3 of benzoyl chloride in 50 cm3 of chloroform. After stirring the mixture at a temperature in the region of 20° C. for 1 hour 30 minutes, 100 cm3 of distilled water were added to the reaction mixture. The chloroform phase was separated by settling, washed with 2 times 100 cm3 of water, and then dried over magnesium sulfate. After filtering through paper, the chloroform solution was concentrated under reduced pressure (5 kPa) at a temperature in the region of 40° C. 25 g of (3R,4R)-1-benzoyl-4-[3-(6-methoxyquinolin-4-yl)propyl]-3-vinylpiperidine were obtained in the form of a brown oil.

Provenance & Evidence