Water → HCID 86758140, compound

Participants

Reaction Conditions

Reaction Steps

0.3 g of (prop-2-ynyl) (3R,4R)-4-[3-(6-methoxyquinolin-4-yl)propyl]-1-(prop-2-ynyl)piperidine-3-carboxylate in 3 cm3 of dioxane and 1.48 cm3 of N sodium hydroxide were heated, with stirring, at a temperature in the region of 70° C. for 17 hours. The reaction mixture was concentrated under reduced pressure (5 kPa) at a temperature in the region of 50° C. 1.48 cm3 of normal aqueous hydrochloric acid were added to the solid residue obtained, followed by 10 cm3 of water. The solution obtained was extracted with 5 times 20 cm3 of dichloromethane. The organic extracts were combined and then concentrated under reduced pressure (5 kPa). 0.189 g of (3R,4R)-4-[3-(6-methoxyquinolin-4-yl)propyl]-1-(prop-2-ynyl)piperidine-3-carboxylic acid was obtained in the form of a foam with a white color.

Provenance & Evidence