Hydroxide → HCID 21347708, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 0.37 g of methyl (3R,4R)-4-[3-(6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)propyl]piperidine-3-carboxylate in 6 cm3 of dioxane, to which dioxane had been added 1.6 cm3 of N aqueous hydroxide, was stirred at a temperature in the region of 60° C. for 20 hours. After evaporating the solvents under reduced pressure (5 kPa) at a temperature in the region of 45° C., the residue obtained was taken up in 20 cm3 of water and then the aqueous phase was washed with 20 cm3 of ethyl ether. After separating the ether by settling, the aqueous phase was neutralized with 1.6 cm3 of N hydrochloric acid and then extracted with 2 times 30 cm3 of ethyl acetate. The combined extracts were dried over magnesium sulfate. The organic solution, after filtration, was evaporated under reduced pressure (5 kPa) at a temperature in the region of 40° C. 0.21 g of (3R,4R)-4-[3-(6-methoxyquinolin-4-yl)propyl]-1 -[3-(thien-2- yl)propyl]piperidine-3-carboxylic acid was obtained in the form of a foam with a beige color which melts at approximately 60° C. with softening.

Provenance & Evidence