Hydrochloric Acid → HCID 70174049, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 0.5 g of methyl (3R,4R)-4-[3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(pyridin-2-ylthio)ethyl]piperidine-3-carboxylate in 7.8 cm3 of 6N hydrochloric acid was heated with stirring at a temperature in the region of 100° C. for 2 hours. After concentrating the reaction mixture to dryness under reduced pressure (5 kPa) at a temperature in the region of 80° C. the residue obtained was triturated in 10 cm3 of diisopropyl ether. The insoluble material was filtered off and then dried under reduced pressure (13 kPa) at a temperature in the region of 60° C. 0.55 g of (3R,4R)-4-[3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(pyridin-2-ylthio)ethyl]piperidine-3-carboxylic acid trihydrochloride was obtained in the form of a solid with a cream color which melts with softening in the region of 165° C.

Provenance & Evidence