Hydrochloric Acid → HCID 70172587, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.45 g of methyl (3R,4R)-4-[3-(R,S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylthio)ethyl]piperidine-3-carboxylate, 3.5 cm3 of methanol, and 0.54 cm3 of 5N aqueous sodium hydroxide was heated with stirring at a temperature in the region of 60° C. for 20 hours. After evaporating the solvents under reduced pressure (5 kPa) at a temperature in the region of 40° C., the residue obtained was taken up in 3 cm3 of a 6N aqueous hydrochloric acid solution. The solution was evaporated under the same conditions and then the residue obtained was triturated in a dichloromethane/methanol (90/10 by volume) mixture. The insoluble material was filtered off and washed with 2 times 1 cm3 of this mixture. The filtrate was dried over sodium sulfate and then concentrated under reduced pressure (5 kPa) at a temperature in the region of 4° C. After drying in the air, 0.16 g of (3R,4R)-4-[3-(R,S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylthio)ethyl]piperidine-3-carboxylic acid dihydrochloride was obtained in the form of a beige solid which melts, with softening, at approximately 148° C.

Provenance & Evidence