Hydrochloric Acid → HCID 70172163, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 0.2 g of methyl (3R,4R)-4-[3-(R,S)-fluoro-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylthio)ethyl]piperidine-3-carboxylate in 3 cm3 of 6N aqueous hydrochloric acid was heated with stirring at a temperature in the region of 100° C. for 7 hours and then evaporated under reduced pressure (5 kPa) at a temperature in the region of 50° C. The residue obtained was stirred in 10 cm3 of diisopropyl ether. The crystals which resulted therefrom were filtered off, washed with 2 times 5 cm3 of diisopropyl ether, and dried under reduced pressure (13 Pa) at a temperature in the region of 60° C. 0.22 g of (3R,4R)-4-[3-(R,S)-fluoro-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylthio)ethyl]piperidine-3-carboxylic acid dihydrochloride were obtained in the form of a solid with a beige color melting with softening at a temperature in the region of 140° C.

Provenance & Evidence