Sodium Hydroxide → HCID 69353107, compound

HRID 2186395Notes

Reaction equation

HRID 2186395 reaction equation
[OH:1][CH:2]([C:24]1[C:33]2[C:28](=[CH:29][CH:30]=[C:31]([O:34][CH3:35])[CH:32]=2)[N:27]=[CH:26][CH:25]=1)[CH2:3][CH2:4][C@@H:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]#[C:13][C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)[CH2:7][C@@H:6]1[CH2:19][C:20]([O:22]C)=[O:21].[OH-].[Na+]>O1CCOCC1.C(OCC)C>[OH:1][CH:2]([C:24]1[C:33]2[C:28](=[CH:29][CH:30]=[C:31]([O:34][CH3:35])[CH:32]=2)[N:27]=[CH:26][CH:25]=1)[CH2:3][CH2:4][C@@H:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]#[C:13][C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)[CH2:7][C@@H:6]1[CH2:19][C:20]([OH:22])=[O:21]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 131723290HCID 131723290, compound

Product 1

HCID 69353107HCID 69353107, compoundYield 65.2%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
60 °C

Procedure

A solution of 3 g of methyl (3R,4R)-4-[3-(R,S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-3-acetate in 50 cm3 of dioxane to which had been added 5 cm3 of 5N aqueous sodium hydroxide solution was heated for 17 hours, with stirring and under an inert atmosphere, at a temperature in the region of 60° C. After cooling to approximately 20° C., the mixture was concentrated under reduced pressure (5 kPa) at a temperature in the region of 40° C. and then the residue was taken up in 100 cm3 of dichloromethane and 5 cm3 of water. The mixture was acidified with an amount of citric acid sufficient to obtain a pH in the region of 4-5 and then dried over magnesium sulfate, filtered, and concentrated as above. The residual water was entrained by azeotroping in chloroform. After concentrating as above, the residue obtained was purified by chromatography at atmospheric pressure on a column of silica gel (particle size 20-45 μm; diameter 3.5 cm; silica volume 200 cm3), elution was carried out with a chloroform/methanol/28% aqueous ammonia (12/2/0.5 by volume) mixture, and approximately 60-cm3 fractions were collected. The fractions comprising the expected product were combined and then concentrated under reduced pressure (5 kPa) at a temperature in the region of 40° C. The residue obtained was taken up in 40 cm3 of diethyl ether, filtered off, washed with 2 times 5 cm3 of ether, and dried under reduced pressure (5 kPa) at a temperature in the region of 20° C. and then in an oven under reduced pressure (10 Pa) at a temperature in the region of 40° C. 1.9 g of (3R,4R)-4-[3-(R,S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-3-acetic acid were obtained in the form of a white solid.

Workup

  1. temperaturewas heated for 17 hours
  2. temperatureAfter cooling to approximately 20° C.
  3. concentrationthe mixture was concentrated under reduced pressure (5 kPa) at a temperature in the region of 40° C.
  4. customto obtain a pH in the region of 4-5
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated as above
  8. customby azeotroping in chloroform
  9. concentrationAfter concentrating as above, the residue
  10. customobtained
  11. customwas purified by chromatography at atmospheric pressure on a column of silica gel (particle size 20-45 μm; diameter 3.5 cm; silica volume 200 cm3), elution
  12. customwere collected
  13. concentrationconcentrated under reduced pressure (5 kPa) at a temperature in the region of 40° C
  14. customThe residue obtained
  15. filtrationfiltered off
  16. washwashed with 2 times 5 cm3 of ether
  17. customdried under reduced pressure (5 kPa) at a temperature in the region of 20° C.
  18. customin the region of 40° C

Sources & evidence

ORD record
ord-8330f5fc4b86475cb033b2fa7050aa5c
Source dataset
uspto-grants-2002_06
Patent number
US06403610B1

Reaction notes

Loading…