HCID 14755365, compound → HCID 22456178, compound

HRID 2186418Notes

Reaction equation

HRID 2186418 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=O)[CH2:7][C:8]([CH3:13])([CH3:12])[O:9]2)=[CH:4][CH:3]=1.[C:15]([Mg]Cl)([CH3:18])([CH3:17])[CH3:16]>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:15]([CH3:18])([CH3:17])[CH3:16])=[CH:7][C:8]([CH3:13])([CH3:12])[O:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14755365HCID 14755365, compound2×HCID 178418310HCID 178418310, compound

Product 1

HCID 22456178HCID 22456178, compound

Procedure

7-bromo-2,2-dimethyl-chroman-4-one (Compound 65, 1.8 g, 7 mmol) was treated by the procedure described immediately above (using t-butylmagnesium chloride) to produce the title compound as a clear oil: (500 mg, 25%).

Sources & evidence

ORD record
ord-f61f2b5480a4447a807bcfdbc486a3a9
Source dataset
uspto-grants-2002_06
Patent number
US06403638B1

Reaction notes

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